Transglutaminase 2—a novel inhibitor of adipogenesis
نویسندگان
چکیده
منابع مشابه
A Novel Therapeutic Target in Inflammatory Uveitis: Transglutaminase 2 Inhibitor
PURPOSE Our goal was to investigate the effects of inhibition of transglutaminase 2 (TGase 2) on endotoxin-induced uveitis (EIU) METHODS: EIU was induced in female Lewis rats by single footpad injections of 200 microg of lipopolysaccharide (LPS). TGase 2 inhibitors were administered intraperitoneally 30 minutes before and at the time of LPS administration. Rats were sacrificed 24 hours after in...
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Transglutaminase 2 (TG2) is a ubiquitous enzyme which catalyzes the crosslinking of proteins via formation of epsilon-(gamma-glutamyl) lysine bonds as well as deamidation of glutamine residues to glutamate in suitable substrates. The activity of Transglutaminase 2 has been implicated in the pathology of several diseases including Celiac Disease and diseases involving protein aggregation such as...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2015
ISSN: 2041-4889
DOI: 10.1038/cddis.2015.238